The production of recombinant proteins (r-proteins) has been an important technology over the last twenty years with the one main focus being on biopharmaceutical products with medical applications. Most r-proteins in this category are complex molecules that need to be post-translationally modified for full bioactivity. As such modifications are only accurately performed by mammalian cells, they have become the major host for complex r-protein expression. This PhD project will be carried out at CPR, and aims to implement and further develop the mammalian cells transfection and expression platform. Our unit is equipped with state-of-the-art facilities, two cell culture laboratories equipped with the newest and cutting-edge instruments. We aim at continuously improving our platform, hereby allowing for rapid and cost-effective production of high quality recombinant human proteins. The candidate should be able to conduct independent and creative research, demonstrate scientific productivity, and show good inter-personal and communication skills.
-The candidate is required to have a M.Sc. or equivalent degree in natural or medical science. -Excellent academic track record. -Prior experience in molecular biology, cell culture and/or protein chemistry techniques is desirable. -Knowledge in one or more of the following area(s) would be considered an advantage: protein purification, high-throughput cloning and expression and/or mammalian cell culture techniques. -Good communication skills, both oral and written. – An analytical aptitude for devising innovative scientific or technical solutions. – Demonstrate enthusiasm, motivation, flexibility and confidence.